In Spider-Man 2, this building houses Dr. Otto Octavius's laboratory, where he demonstrates his fusion reactor to the press.
At the start of Spiderman 2, Peter Parker has a job delivering pizza's at Joe's Pizza (the original location closed).
The cult leader of the Left-Hand Path concocted a scheme to capture the Werewolf by the Knight here and gain the power of the Beast. This is where the cult and Moon Knight fight.
The Supervillian team of Mr. Hyde and Cobra once broke into the Guggenheim to steal toys that were valuable collector's items on behalf of their ally the Jester.
This is where John Jameson was to marry Mary Jane Watson at the end of Spiderman 2.
In Spiderman, Peter Parker's Uncle Ben is shot and killed across 5th Ave from the library.
Fleeing her wedding to John Jameson, Mary Jane runs across Madison Square Park in Spiderman 2 to reach Peter Parker's Apartment.
In Spiderman 2, Doctor Octopus hurls a car through the window of a restaurant in Astor Place, nearly killing Peter Parker and Mary Jane.
The school that Peter Parker attended (Midtown High School) is based on this school.
